The detection of anti-CCP is carried out with the second generation ELISA technique (anti-CCP2) that modifies the peptide structure of the antibodies and makes them highly reactive and that has sensitivity of 68.5% (39-94%) and specificity of 97% (81-100%), 1 being under study a method of detection of anti-CCP of third generation that theoretically offers greater sensitivity and specificity, advantages not yet proven.
However, anti-citrulline antibodies are not specific either Flekosteel, since they are accompanied by false positives due to their presence in other rheumatological diseases (Sjögren's syndrome, systemic lupus erythematosus, Wegener's granulomatosis, ankylosing spondylitis, psoriatic arthritis) .
No comments:
Post a Comment